06. Identification of optimal subcutaneous doses of tocilizumab in children with polyarticular-course juvenile idiopathic arthritis
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چکیده
منابع مشابه
Subcutaneous golimumab for children with active polyarticular-course juvenile idiopathic arthritis: results of a multicentre, double-blind, randomised-withdrawal trial
OBJECTIVE This report aims to determine the safety, pharmacokinetics (PK) and efficacy of subcutaneous golimumab in active polyarticular-course juvenile idiopathic arthritis (polyJIA). METHODS In this three-part randomised double-blinded placebo-controlled withdrawal trial, all patients received open-label golimumab (30 mg/m2 of body surface area; maximum: 50 mg/dose) every 4 weeks together w...
متن کاملAdvances in the treatment of polyarticular juvenile idiopathic arthritis
PURPOSE OF REVIEW To review recent advances in the management strategies of polyarticular course juvenile idiopathic arthritis (JIA) and identify unanswered questions and avenues for further research. RECENT FINDINGS There is evidence for an early, aggressive, treat-to-target approach for polyarticular JIA. Clinical disease activity criteria have been recently defined and validated, including...
متن کاملAdministration of routine preventative vaccinations in children with polyarticular juvenile idiopathic arthritis receiving adalimumab
Methods Pts with active pJIA were enrolled in one of the following trials: M10-444 (ages 2 to <4 or ≥4 weighing <15 kg in US, EU), M10-240 (ages 4-17 in Japan), DE038 (ages 4-17 in US, EU) or the STRIVE (P10-262) registry (ages 4-17 in US, EU, and Australia). Pts received ADA±methotrexate. Vaccinations were administered based on the judgment of the study investigator or the treating physician. ...
متن کاملPredictors of response to etanercept in polyarticular-course juvenile idiopathic arthritis.
OBJECTIVE The aim of this study was to determine demographic, clinical, articular and laboratory variables predicting etanercept response in JIA. METHODS A total of 863 patients registered in the BIKER registry were included. Predictors of response for ACR paediatric criteria (PedACR) 30, 70 and 90 were analysed by bivariate analysis and logistic regression. RESULTS After 6 months, 81.9% of...
متن کاملEffects of antirheumatic treatment with tocilizumab on longitudinal growth in children with juvenile idiopathic arthritis
Methods Nineteen patients with systemic JIA was included into the study (8 boys and 11 girls). The mean age at first visit was 6.8 ± 2.4 years, and disease duration 4 (2,2;6) years. All patients had stage 1 of sexual development by Tanner scale and before therapy with tocilizumab had standard antirheumatic therapy. Anthropometric parameters were estimated one year before tocilizumab treatment, ...
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ژورنال
عنوان ژورنال: Rheumatology
سال: 2017
ISSN: 1462-0324,1462-0332
DOI: 10.1093/rheumatology/kex356.052